Aiming at the injured heart

Nanoelectronics aiming at cancer.

Featured Article: Zheng GF, Patolsky F, Cui Y, Wang WU, Lieber CM. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotechnol 2005;23:1294–301. There are 200 types of cancers, each with many variants. The devastating effects of cancer on patients and their families extract a huge loss. For instance, nearly 1.5 million people in the US alone are diagnosed with...

Text Structure Aiming at Machine Translation Text Structure Aiming at Machine Translation

STRUCTURE ASSEMBLER STRUCTURE ASSEMBLER STRUCTURE SPAN Figure 6: Meaning Representation Construction These processes operate on the following components of the meaning representation: Propositions: are produced as a result of syntactic and semantic analysis. Semantic and Syntactic Signals: guide the coherence assembler in the selection of the coherence relations and also in deciding where a coh...

Aiming at WM with both barrels blocked.

How can a therapy be targeted to cancer if the target is in every normal cell? Because proteasomes are found in all nucleated as well as anucleated cells, it could be argued that this target is even less cancer-specific than that of conventional DNA-damaging chemotherapy. However, proteasome inhibitors clearly have made an impact in the treatment of many types of cancer and none bigger than in ...

[Pharmaceutical basic researches aiming at clinical applications].

Aiming drug discovery at lysophosphatidic acid targets

Lysophosphatidic acid (LPA, 1-radyl-2-hydroxy-sn-glycero-3-phosphate) is the prototype member of a family of lipid mediators and second messengers. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and a nuclear hormone receptor within the cell. In addition, there are several enzymes that utilize LPA as a substrate or generate it as a produc...